10 Best pain relievers of 2025

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Best Choice

1

Aleve
Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count
Main highlights

12-Hour Pain Relief
Aleve provides up to 12 hours of uninterrupted pain relief, ideal for back and muscle pain.

Ideal for Back Pain
Specially formulated for quick relief from back and muscle pain, perfect for active individuals.

Quick Pain Relief
Customers praise its fast-acting relief for back and muscle pain compared to other variants.
Key specs
- Tablet Form:Small, easy-to-swallow
- Active Ingredient:220 mg naproxen sodium
- Targeted Relief:Back & muscle pain
- Dosage:Use as directed
- Fever Reducer:Yes, for 12+
9.7

Exceptional

Our Rating

9.5
worth the money

9.5
pain management
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Based on millions of stores and reviews

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Value for Money

2

Advil
Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count, Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate - 2 Count
Main highlights

Key Features
Advil reduces fever and relieves pain for up to 6 hours; eco-friendly packaging reduces plastic use.

Ideal Use Cases
Perfect for treating headaches, arthritis, back pain, and aids in a restful sleep for those with minor aches.

Customer Praise
Users highly value its effectiveness in pain relief and its ability to improve sleep quality.
9.4

Excellent

Our Rating

9.5
simple to consume

9.1
pain management

8.4
worth the money
3

Amazon Basic Care
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)
Main highlights

Effective Pain and Fever Relief
Contains 500 mg of Acetaminophen, similar to Tylenol, for relieving minor aches and reducing fever.

Ideal for Everyday Aches
Perfect for headaches, arthritis, colds, and menstrual cramps in adults and children over 12.

Great Value for Money
Customers appreciate the cost-effectiveness and comparable performance to name brands.
9.2

Excellent

Our Rating
4

Amazon Basic Care
Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)
Main highlights

Pain Relief and Fever Reduction
Contains 200 mg ibuprofen for effective pain and fever relief.

Ideal for Various Aches
Perfect for muscular aches, arthritis, toothache, backache, and more.

Best Price and Convenience
Praised for affordability and convenience of Amazon delivery.
9.1

Excellent

Our Rating

9.9
simple to consume

9.5
pain management

9.3
worth the money
5

Tylenol
Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

24% Off
Main highlights

Fast Acting Relief
100-count Tylenol Extra Strength Rapid Release Gels work quickly to relieve pain and reduce fever with 500 mg acetaminophen.

Ideal for Adults and Teens
Suitable for adults and children 12 years and older, making it versatile for family use.

Highly Praised Effectiveness
Customers appreciate the fast action and effectiveness, noting the rapid relief and long-lasting results.
Key specs
- form:Rapid release gels
- active ingredient:Acetaminophen 500mg
- pain relief:Extra strength
- dosing instructions:Adults and children 12+
- age suitability:12 years and older
9.0

Excellent

Our Rating

9.7
simple to consume

9.5
worth the money

9.5
pain management
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6

Advil
Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Tablets
Main highlights

Long-lasting Relief
Advil provides up to 6 hours of pain relief for headaches, backaches, and more.

Versatile Pain Management
Ideal for headache, backache, menstrual pain, joint pain, and minor arthritis.

Customer Satisfaction
Praised for its effectiveness and availability, despite potential side effects.
8.8

Very Good

Our Rating

9.9
For traveling

9.9
simple to consume

9.7
worth the money
7

Advil
Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 200 Coated Tablets

11% Off
Main highlights

Key Features and Benefits
Advil offers longer lasting relief than Tylenol Extra Strength, with a new eco-friendly package reducing plastic use by 20%.

Ideal Use Cases
Effective for headaches, menstrual pain, backache, joint pain, and minor arthritis, suitable for adults and children over 12.

Customer Reviews Highlight
Most reviews praise Advil for its quick, effective pain relief and the easy-to-swallow coated tablets.
8.6

Very Good

Our Rating

9.9
pain management

9.7
simple to consume

9.7
worth the money
8

Tylenol
Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever and Fever Reducer for Headache, Backache, Toothache & Minor Arthritis Pain Relief, 100 Count
Main highlights

Effective Pain Relief and Fever Reduction
Tylenol Extra Strength Caplets provide 500 mg of acetaminophen for temporary relief of minor aches and fever.

Versatile Use for Common Ailments
Ideal for headaches, backaches, toothaches, menstrual cramps, and cold-related pain.

Convenient and Trusted by Customers
Praised for its effectiveness and convenience of home delivery at competitive prices.
Key specs
- form:Caplets
- active ingredient:Acetaminophen 500 mg
- pain relief:Minor aches and pains
- dosing instructions:Two caplets every six hours
- age suitability:12 years and older
8.5

Good

Our Rating

9.7
simple to consume

9.7
pain management

9.5
worth the money
9

Tylenol
Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen for Minor Arthritis & Joint Pain, Fever Reducer, Extended Release, Gentle on Stomach, FSA or HSA Eligible, 100 ct
Main highlights

Fast-Acting Extended Relief
Tylenol 8HR provides fast, temporary relief for minor arthritis pain with 650 mg acetaminophen.

Ideal for Arthritis Sufferers
Best suited for those needing relief from joint pain in hands, knees, and more.

Highly Praised for Pain Management
Customers appreciate its effectiveness in controlling pain without narcotics.
Key specs
- form:Caplets
- active ingredient:Acetaminophen
- pain relief:Arthritis, joint pain
- dosing instructions:Adults 18+, two caplets
- age suitability:Adults 18+
8.2

Good

Our Rating

9.3
worth the money

9.3
Long life

9.3
pain management
10

Advil
Advil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count
Main highlights

Dual Pain Relief Formula
Combines 250mg Ibuprofen and 500mg Acetaminophen for 8-hour relief.

Versatile Pain Relief
Ideal for back pain, headaches, toothaches, menstrual cramps, and muscle pain.

Convenience and Trust
Praised for its convenience and trusted brand reliability.
Key specs
- form:Caplets
- active ingredient:Ibuprofen, Acetaminophen
- pain relief:8 hours
- dosing instructions:N/A
- age suitability:N/A
8.1

Good

Our Rating

10 Best pain relievers of 2025

1

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

9.5

9.5

How do we rank?

How do we rank?

Analyzing top stores

2

Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count, Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate - 2 Count

9.5

9.1

8.4

3

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

4

Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)

9.9

9.5

9.3

5

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

9.7

9.5

9.5

6

Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Tablets

9.9

9.9

9.7

7

Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 200 Coated Tablets

9.9

9.7

9.7

8

Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever and Fever Reducer for Headache, Backache, Toothache & Minor Arthritis Pain Relief, 100 Count

9.7

9.7

9.5

9

Tylenol 8HR Arthritis Pain Relief Caplets, 650 mg Acetaminophen for Minor Arthritis & Joint Pain, Fever Reducer, Extended Release, Gentle on Stomach, FSA or HSA Eligible, 100 ct

9.3

9.3

9.3

10

Advil Dual Action Back Pain Caplets Delivers 125mg Ibuprofen and 250mg Acetaminophen Per Dose for 8 Hours of Back Pain Relief - 144 Count

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